The disease may develop earlier in each successive generation. Symptoms usually begin between 30 and 50 years of age but can start at any age. The specific symptoms vary somewhat between people. Mental abilities generally decline into dementia. Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk. As the disease advances, uncoordinated, involuntary body movements of chorea become more apparent. It is also a basal ganglia disease causing a hyperkinetic movement disorder known as chorea. A general lack of coordination and an unsteady gait often follow. The earliest symptoms are often subtle problems with mood or mental abilities. Huntington's disease ( HD), also known as Huntington's chorea, is a neurodegenerative disease that is mostly inherited. Sydenham's chorea, benign hereditary chorea, lupus, paraneoplastic syndrome, Wilson's disease Pneumonia, heart disease, physical injury from falls, suicide Problems with motor skills, including coordination and gait, mood, and mental abilities An edited microscopic image of a medium spiny neuron (yellow) with an inclusion body (orange), which occurs as part of the disease process (image width 360 µm)
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